Covariation among factors that may affect nest success of dabbling ducks in the Prairie Pothole Region of North America (e.g. productivity of upland and wetland habitat related to climate variation, and duck and predator densities) often confounds efforts to interpret the effect of any individual factor. A comparison of nest success of dabbling ducks at sites with and without predator management provided an opportunity to separate the effect of predation pressure from other factors because predator management has occurred over a range of climatic conditions. We updated an existing study on temporal trends of nest success for prairie ducks in the Prairie Pothole Region of North America by compiling recent estimates of nest success for five species of dabbling ducks (Mallard [Anas platyhrynchos], Northern Pintail [A. acuta], Northern Shoveler [A. clypeata], Blue-winged Teal [A. discors], and Gadwall [A. strepera]). In addition, we compared trends of nest success at unmanaged sites and sites where nest predators were excluded or removed. We used pond density calculated from annual surveys for breeding waterfowl as an index of upland and wetland productivity and a correlate of predator and duck density. At unmanaged sites, the best approximating local regression model suggested that, rather than having undergone a monotonic decline, average nest success has fluctuated through time, although those changes do not appear to be associated with changes in pond density. At sites where predators were excluded, nest success did not vary with time but varied positively with pond density in the previous year, although that effect was tempered by high pond density in the year of observation. At sites where predators were removed but could emigrate back into study plots, nest success varied widely over time and we found no evidence of an effect of pond density. We show that nest success of dabbling ducks is higher under predator management than at sites without predator management, and that this relationship varies with climatic conditions, possibly related to complex interactions within and among duck species, their predators, and their prey.